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Activation of G Protein–Coupled Receptors: Beyond Two-State Models and Tertiary Conformational Changes
Transformation of G protein–coupled receptors (GPCRs) from a quiescent to an active state initiates signal transduction. All GPCRs share a common architecture comprising seven transmembrane-spanning α-helices, which accommodates signal propagation from a diverse repertoire of external stimuli across...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2639654/ https://ncbi.nlm.nih.gov/pubmed/17848137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev.pharmtox.48.113006.094630 |
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