Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry

IMPORTANCE: Li-Fraumeni syndrome, usually characterized by germline TP53 mutations, is associated with markedly elevated lifetime risks of multiple cancers, and has been linked to an increased risk of early-onset colorectal cancer. OBJECTIVE: To examine the frequency of germline TP53 alterations in...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:JAMA Oncol
Autori principali: Yurgelun, Matthew B., Masciari, Serena, Joshi, Victoria A., Mercado, Rowena C., Lindor, Noralane M., Gallinger, Steven, Hopper, John L., Jenkins, Mark A., Buchanan, Daniel D., Newcomb, Polly A., Potter, John D., Haile, Robert W., Kucherlapati, Raju, Syngal, Sapna
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465271/
https://ncbi.nlm.nih.gov/pubmed/26086041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.0197
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi