Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry

IMPORTANCE: Li-Fraumeni syndrome, usually characterized by germline TP53 mutations, is associated with markedly elevated lifetime risks of multiple cancers, and has been linked to an increased risk of early-onset colorectal cancer. OBJECTIVE: To examine the frequency of germline TP53 alterations in...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:JAMA Oncol
मुख्य लेखकों: Yurgelun, Matthew B., Masciari, Serena, Joshi, Victoria A., Mercado, Rowena C., Lindor, Noralane M., Gallinger, Steven, Hopper, John L., Jenkins, Mark A., Buchanan, Daniel D., Newcomb, Polly A., Potter, John D., Haile, Robert W., Kucherlapati, Raju, Syngal, Sapna
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465271/
https://ncbi.nlm.nih.gov/pubmed/26086041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.0197
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