Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry and mismatch repair germline mutation screening

Microsatellite instability (MSI) occurs in 10−20% of colorectal cancers (CRC), and has been attributed to both MLH1 promoter hypermethylation and germline mutation in the mismatch repair (MMR) genes. We present results from a large population- and clinic-based study of MLH1 methylation, immunohistoc...

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Main Authors: Poynter, Jenny N., Siegmund, Kimberly D., Weisenberger, Daniel J., Long, Tiffany I., Thibodeau, Stephen N., Lindor, Noralane, Young, Joanne, Jenkins, Mark A., Hopper, John L., Baron, John A., Buchanan, Dan, Casey, Graham, Levine, A. Joan, Marchand, Loïc Le, Gallinger, Steven, Bapat, Bharati, Potter, John D., Newcomb, Polly A., Haile, Robert W., Laird, the Colon Cancer Family Registry Investigators, and Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628332/
https://ncbi.nlm.nih.gov/pubmed/18990764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-08-0512
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