Specific Variants in the MLH1 Gene Region May Drive DNA Methylation, Loss of Protein Expression, and MSI-H Colorectal Cancer

BACKGROUND: We previously identified an association between a mismatch repair gene, MLH1, promoter SNP (rs1800734) and microsatellite unstable (MSI-H) colorectal cancers (CRCs) in two samples. The current study expanded on this finding as we explored the genetic basis of DNA methylation in this regi...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Mrkonjic, Miralem, Roslin, Nicole M., Greenwood, Celia M., Raptis, Stavroula, Pollett, Aaron, Laird, Peter W., Pethe, Vaijayanti V., Chiang, Theodore, Daftary, Darshana, Dicks, Elizabeth, Thibodeau, Stephen N., Gallinger, Steven, Parfrey, Patrick S., Younghusband, H. Banfield, Potter, John D., Hudson, Thomas J., McLaughlin, John R., Green, Roger C., Zanke, Brent W., Newcomb, Polly A., Paterson, Andrew D., Bapat, Bharati
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954166/
https://ncbi.nlm.nih.gov/pubmed/20967208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013314
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires