Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients

Aberrant activation of canonical Wnt signaling is a hallmark event in colorectal carcinogenesis. The Dickkopf-1 (DKK1) and Secreted Frizzled Related Protein 1 (SFRP1) genes encode extracellular inhibitors of Wnt signaling that are frequently silenced by promoter hypermethylation in colorectal cancer...

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Библиографические подробности
Главные авторы: Rawson, James B., Manno, Michael, Mrkonjic, Miralem, Daftary, Darshana, Dicks, Elizabeth, Buchanan, Daniel D., Younghusband, H. Banfield, Parfrey, Patrick S., Young, Joanne P., Pollett, Aaron, Green, Roger C., Gallinger, Steven, McLaughlin, John R., Knight, Julia A., Bapat, Bharati
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2011
Предметы:
Molecular Epidemiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140140/
https://ncbi.nlm.nih.gov/pubmed/21304055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr020
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