Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

BACKGROUND: Aberrant Wnt signaling activation occurs commonly in colorectal carcinogenesis, leading to upregulation of many target genes. APC (adenomatous polyposis coli) is an important component of the β-catenin destruction complex, which regulates Wnt signaling, and is often mutated in colorectal...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Savio, Andrea J., Daftary, Darshana, Dicks, Elizabeth, Buchanan, Daniel D., Parfrey, Patrick S., Young, Joanne P., Weisenberger, Daniel, Green, Roger C., Gallinger, Steven, McLaughlin, John R., Knight, Julia A., Bapat, Bharati
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756469/
https://ncbi.nlm.nih.gov/pubmed/26884349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2149-9
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