Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

BACKGROUND: Aberrant Wnt signaling activation occurs commonly in colorectal carcinogenesis, leading to upregulation of many target genes. APC (adenomatous polyposis coli) is an important component of the β-catenin destruction complex, which regulates Wnt signaling, and is often mutated in colorectal...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Cancer
Auteurs principaux: Savio, Andrea J., Daftary, Darshana, Dicks, Elizabeth, Buchanan, Daniel D., Parfrey, Patrick S., Young, Joanne P., Weisenberger, Daniel, Green, Roger C., Gallinger, Steven, McLaughlin, John R., Knight, Julia A., Bapat, Bharati
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756469/
https://ncbi.nlm.nih.gov/pubmed/26884349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2149-9
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