Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients

Aberrant activation of canonical Wnt signaling is a hallmark event in colorectal carcinogenesis. The Dickkopf-1 (DKK1) and Secreted Frizzled Related Protein 1 (SFRP1) genes encode extracellular inhibitors of Wnt signaling that are frequently silenced by promoter hypermethylation in colorectal cancer...

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Detalles Bibliográficos
Autores principales: Rawson, James B., Manno, Michael, Mrkonjic, Miralem, Daftary, Darshana, Dicks, Elizabeth, Buchanan, Daniel D., Younghusband, H. Banfield, Parfrey, Patrick S., Young, Joanne P., Pollett, Aaron, Green, Roger C., Gallinger, Steven, McLaughlin, John R., Knight, Julia A., Bapat, Bharati
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2011
Materias:
Molecular Epidemiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140140/
https://ncbi.nlm.nih.gov/pubmed/21304055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr020
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