Specific Variants in the MLH1 Gene Region May Drive DNA Methylation, Loss of Protein Expression, and MSI-H Colorectal Cancer

BACKGROUND: We previously identified an association between a mismatch repair gene, MLH1, promoter SNP (rs1800734) and microsatellite unstable (MSI-H) colorectal cancers (CRCs) in two samples. The current study expanded on this finding as we explored the genetic basis of DNA methylation in this regi...

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Detalhes bibliográficos
Main Authors: Mrkonjic, Miralem, Roslin, Nicole M., Greenwood, Celia M., Raptis, Stavroula, Pollett, Aaron, Laird, Peter W., Pethe, Vaijayanti V., Chiang, Theodore, Daftary, Darshana, Dicks, Elizabeth, Thibodeau, Stephen N., Gallinger, Steven, Parfrey, Patrick S., Younghusband, H. Banfield, Potter, John D., Hudson, Thomas J., McLaughlin, John R., Green, Roger C., Zanke, Brent W., Newcomb, Polly A., Paterson, Andrew D., Bapat, Bharati
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954166/
https://ncbi.nlm.nih.gov/pubmed/20967208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013314
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