Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry

IMPORTANCE: Li-Fraumeni syndrome, usually characterized by germline TP53 mutations, is associated with markedly elevated lifetime risks of multiple cancers, and has been linked to an increased risk of early-onset colorectal cancer. OBJECTIVE: To examine the frequency of germline TP53 alterations in...

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Publicado no:JAMA Oncol
Main Authors: Yurgelun, Matthew B., Masciari, Serena, Joshi, Victoria A., Mercado, Rowena C., Lindor, Noralane M., Gallinger, Steven, Hopper, John L., Jenkins, Mark A., Buchanan, Daniel D., Newcomb, Polly A., Potter, John D., Haile, Robert W., Kucherlapati, Raju, Syngal, Sapna
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465271/
https://ncbi.nlm.nih.gov/pubmed/26086041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.0197
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