Spatiotemporally Regulated Ablation of Klf4 in Adult Mouse Corneal Epithelial Cells Results in Altered Epithelial Cell Identity and Disrupted Homeostasis

PURPOSE. In previous studies, conditional disruption of Klf4 in the developing mouse ocular surface from embryonic day 10 resulted in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells, revealing the importance of Klf4 in ocular surface maturation. Here, we use spatio...

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Bibliografski detalji
Izdano u:Invest Ophthalmol Vis Sci
Glavni autori: Delp, Emili E., Swamynathan, Sudha, Kao, Winston W., Swamynathan, Shivalingappa K.
Format: Artigo
Jezik:Inglês
Izdano: The Association for Research in Vision and Ophthalmology 2015
Teme:
Cornea
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464104/
https://ncbi.nlm.nih.gov/pubmed/26047041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16463
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