Spatiotemporally Regulated Ablation of Klf4 in Adult Mouse Corneal Epithelial Cells Results in Altered Epithelial Cell Identity and Disrupted Homeostasis

PURPOSE. In previous studies, conditional disruption of Klf4 in the developing mouse ocular surface from embryonic day 10 resulted in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells, revealing the importance of Klf4 in ocular surface maturation. Here, we use spatio...

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Detalles Bibliográficos
Publicado en:Invest Ophthalmol Vis Sci
Autores principales: Delp, Emili E., Swamynathan, Sudha, Kao, Winston W., Swamynathan, Shivalingappa K.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2015
Materias:
Cornea
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464104/
https://ncbi.nlm.nih.gov/pubmed/26047041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16463
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