Spatiotemporally Regulated Ablation of Klf4 in Adult Mouse Corneal Epithelial Cells Results in Altered Epithelial Cell Identity and Disrupted Homeostasis

PURPOSE. In previous studies, conditional disruption of Klf4 in the developing mouse ocular surface from embryonic day 10 resulted in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells, revealing the importance of Klf4 in ocular surface maturation. Here, we use spatio...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Delp, Emili E., Swamynathan, Sudha, Kao, Winston W., Swamynathan, Shivalingappa K.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2015
Assuntos:
Cornea
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464104/
https://ncbi.nlm.nih.gov/pubmed/26047041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16463
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