Evidence of an epigenetic origin for high-risk 1q21 copy number aberrations in multiple myeloma

Multiple myeloma is a B-cell malignancy stratified in part by cytogenetic abnormalities, including the high-risk copy number aberrations (CNAs) of +1q21 and 17p(−). To investigate the relationship between 1q21 CNAs and DNA hypomethylation of the 1q12 pericentromeric heterochromatin, we treated in vi...

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發表在:Blood
Main Authors: Sawyer, Jeffrey R., Tian, Erming, Heuck, Christoph J., Johann, Donald J., Epstein, Joshua, Swanson, Charles M., Lukacs, Janet L., Binz, Regina Lichti, Johnson, Marian, Sammartino, Gael, Zangari, Maurizio, Davies, Faith E., van Rhee, Frits, Morgan, Gareth J., Barlogie, Bart
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2015
主題:
Lymphoid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463736/
https://ncbi.nlm.nih.gov/pubmed/25943786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-632075
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