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Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

Microglia rapidly mount an inflammatory response to pathogens in the central nervous system (CNS). Heparan sulfate proteoglycans (HSPGs) have been attributed various roles in inflammation. To elucidate the relevance of microglial HSPGs in a pro-inflammatory response we isolated microglia from mice o...

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Pubblicato in:J Biol Chem
Autori principali: O'Callaghan, Paul, Li, Jin-Ping, Lannfelt, Lars, Lindahl, Ulf, Zhang, Xiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463438/
https://ncbi.nlm.nih.gov/pubmed/25869127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634337
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