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Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

Microglia rapidly mount an inflammatory response to pathogens in the central nervous system (CNS). Heparan sulfate proteoglycans (HSPGs) have been attributed various roles in inflammation. To elucidate the relevance of microglial HSPGs in a pro-inflammatory response we isolated microglia from mice o...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: O'Callaghan, Paul, Li, Jin-Ping, Lannfelt, Lars, Lindahl, Ulf, Zhang, Xiao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463438/
https://ncbi.nlm.nih.gov/pubmed/25869127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634337
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