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Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

Microglia rapidly mount an inflammatory response to pathogens in the central nervous system (CNS). Heparan sulfate proteoglycans (HSPGs) have been attributed various roles in inflammation. To elucidate the relevance of microglial HSPGs in a pro-inflammatory response we isolated microglia from mice o...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: O'Callaghan, Paul, Li, Jin-Ping, Lannfelt, Lars, Lindahl, Ulf, Zhang, Xiao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463438/
https://ncbi.nlm.nih.gov/pubmed/25869127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634337
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