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mTORC1 and mTORC2 selectively regulate CD8(+) T cell differentiation

Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4(+) T effector cell subsets. Herein, we show that mTOR complex 1 (mTORC1) and mTORC2 have distinct roles in the generation of CD8(+) T cell effector and memory populations. Evaluation of mice with a T cell–sp...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Pollizzi, Kristen N., Patel, Chirag H., Sun, Im-Hong, Oh, Min-Hee, Waickman, Adam T., Wen, Jiayu, Delgoffe, Greg M., Powell, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463194/
https://ncbi.nlm.nih.gov/pubmed/25893604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77746
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