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Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells
The bacterial CRISPR-Cas9 system has emerged as an effective tool for sequence-specific gene knockout through non-homologous end joining (NHEJ), but it remains inefficient for precise editing of genome sequences. Here we develop a reporter-based screening approach for high-throughput identification...
שמור ב:
| הוצא לאור ב: | Cell Stem Cell |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4461869/ https://ncbi.nlm.nih.gov/pubmed/25658371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.01.003 |
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