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Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells
A now frequently used method to edit mammalian genomes uses the nucleases CRISPR/Cas9 and CRISPR/Cpf1 or the nickase CRISPR/Cas9n to introduce double-strand breaks which are then repaired by homology-directed repair using DNA donor molecules carrying desired mutations. Using a mixture of small molec...
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| Publicado no: | Nat Commun |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5986859/ https://ncbi.nlm.nih.gov/pubmed/29867139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04609-7 |
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