Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells

The bacterial CRISPR-Cas9 system has emerged as an effective tool for sequence-specific gene knockout through non-homologous end joining (NHEJ), but it remains inefficient for precise editing of genome sequences. Here we develop a reporter-based screening approach for high-throughput identification...

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Vydáno v:Cell Stem Cell
Hlavní autoři: Yu, Chen, Liu, Yanxia, Ma, Tianhua, Liu, Kai, Xu, Shaohua, Zhang, Yu, Liu, Honglei, La Russa, Marie, Xie, Min, Sheng, Ding, Qi, Lei S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461869/
https://ncbi.nlm.nih.gov/pubmed/25658371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.01.003
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