Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells

The bacterial CRISPR-Cas9 system has emerged as an effective tool for sequence-specific gene knockout through non-homologous end joining (NHEJ), but it remains inefficient for precise editing of genome sequences. Here we develop a reporter-based screening approach for high-throughput identification...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cell Stem Cell
Main Authors: Yu, Chen, Liu, Yanxia, Ma, Tianhua, Liu, Kai, Xu, Shaohua, Zhang, Yu, Liu, Honglei, La Russa, Marie, Xie, Min, Sheng, Ding, Qi, Lei S.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461869/
https://ncbi.nlm.nih.gov/pubmed/25658371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.01.003
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares