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Crystallization of interleukin-18 for structure-based inhibitor design
Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and acquired immune defense, with its activity being modulated in vivo by its naturally occurring antagonist IL-18 binding protein (IL-18BP). Recent cryst...
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| Gepubliceerd in: | Acta Crystallogr F Struct Biol Commun |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
International Union of Crystallography
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4461335/ https://ncbi.nlm.nih.gov/pubmed/26057800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15006871 |
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