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Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein

Human interleukin-18 (hIL-18) is a cytokine that plays an important role in inflammation and host defense against microbes. Its activity is regulated in vivo by a naturally occurring antagonist, the human IL-18-binding protein (IL-18BP). Functional homologs of human IL-18BP are encoded by all orthop...

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Detalhes bibliográficos
Main Authors: Krumm, Brian, Meng, Xiangzhi, Li, Yongchao, Xiang, Yan, Deng, Junpeng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634891/
https://ncbi.nlm.nih.gov/pubmed/19104048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809086106
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