A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine(®)) is a novel small molecule inhibitor of ribonucleotide reductase (RR) with clinical signs of activity in pancreatic cancer. Therefore, the Phase 2 Consortium (P2C) initiated a trial (two single stage studies with planned interim a...

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Bibliografiske detaljer
Udgivet i:Invest New Drugs
Main Authors: Attia, Steven, Kolesar, Jill, Mahoney, Michelle R., Pitot, Henry C., Laheru, Daniel, Heun, James, Huang, Wei, Eickhoff, Jens, Erlichman, Charles, Holen, Kyle D.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461052/
https://ncbi.nlm.nih.gov/pubmed/18278438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-008-9123-6
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