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Transthyretin sequesters amyloid beta protein and prevents amyloid formation.

The cardinal pathological features of Alzheimer disease are depositions of aggregated amyloid beta protein (A beta) in the brain and cerebrovasculature. However, the A beta is found in a soluble form in cerebrospinal fluid in healthy individuals and patients with Alzheimer disease. We postulate that...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Schwarzman, A L, Gregori, L, Vitek, M P, Lyubski, S, Strittmatter, W J, Enghilde, J J, Bhasin, R, Silverman, J, Weisgraber, K H, Coyle, P K
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1994
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44607/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8078889/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.18.8368
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