Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.

Despite increasing evidence for a pathogenetic role for the beta-amyloid precursor protein (beta APP) in Alzheimer disease, the physiological function of the protein remains unclear. The expression of the neural-specific isoform containing 695 amino acids, beta APP695, is consistent with a role for...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hung, A Y, Koo, E H, Haass, C, Selkoe, D J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50147/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1409654/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.20.9439
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