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Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity

Clostridium difficile is the leading cause of hospital-acquired diarrhea in the United States. The two main virulence factors of C. difficile are the large toxins, TcdA and TcdB, which enter colonic epithelial cells and cause fluid secretion, inflammation, and cell death. Using a gene-trap insertion...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: LaFrance, Michelle E., Farrow, Melissa A., Chandrasekaran, Ramyavardhanee, Sheng, Jinsong, Rubin, Donald H., Lacy, D. Borden
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460460/
https://ncbi.nlm.nih.gov/pubmed/26038560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500791112
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