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Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity
Clostridium difficile is the leading cause of hospital-acquired diarrhea in the United States. The two main virulence factors of C. difficile are the large toxins, TcdA and TcdB, which enter colonic epithelial cells and cause fluid secretion, inflammation, and cell death. Using a gene-trap insertion...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4460460/ https://ncbi.nlm.nih.gov/pubmed/26038560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500791112 |
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