BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells

We recently reported that brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) binds Prohibitin 2 (PHB2) in cytoplasm, thereby causing a loss of function of the PHB2 tumor suppressor in the nuclei of breast cancer cells. However, little is known regarding the mechanism by which BIG3 in...

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Bibliographic Details
Published in:PLoS One
Main Authors: Kim, Nam-Hee, Yoshimaru, Tetsuro, Chen, Yi-An, Matsuo, Taisuke, Komatsu, Masato, Miyoshi, Yasuo, Tanaka, Eiji, Sasa, Mitsunori, Mizuguchi, Kenji, Katagiri, Toyomasa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4460025/
https://ncbi.nlm.nih.gov/pubmed/26052702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127707
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