Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

Estradiol (E2) and the oestrogen receptor-alpha (ERα) signalling pathway play pivotal roles in the proliferative activity of breast cancer cells. Recent findings show that the brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-PHB2) complex plays a crucial role in E2/ERα...

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Udgivet i:Sci Rep
Main Authors: Yoshimaru, Tetsuro, Aihara, Keisuke, Komatsu, Masato, Matsushita, Yosuke, Okazaki, Yasumasa, Toyokuni, Shinya, Honda, Junko, Sasa, Mitsunori, Miyoshi, Yasuo, Otaka, Akira, Katagiri, Toyomasa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431889/
https://ncbi.nlm.nih.gov/pubmed/28500289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01951-6
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