Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions

Xanthohumol (XN) is a natural anticancer compound that inhibits the proliferation of oestrogen receptor-α (ERα)-positive breast cancer cells. However, the precise mechanism of the antitumour effects of XN on oestrogen (E2)-dependent cell growth, and especially its direct target molecule(s), remain(s...

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Udgivet i:Sci Rep
Main Authors: Yoshimaru, Tetsuro, Komatsu, Masato, Tashiro, Etsu, Imoto, Masaya, Osada, Hiroyuki, Miyoshi, Yasuo, Honda, Junko, Sasa, Mitsunori, Katagiri, Toyomasa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258681/
https://ncbi.nlm.nih.gov/pubmed/25483453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07355
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