A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for development. We show that the transcriptional program of hPGCs is distinct from that in mice, with co-expression of somatic specifiers and naive pluripotency genes TFCP2L1 and KLF4. This unique gene regulatory network,...

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Publicado en:Cell
Autores principales: Tang, Walfred W.C., Dietmann, Sabine, Irie, Naoko, Leitch, Harry G., Floros, Vasileios I., Bradshaw, Charles R., Hackett, Jamie A., Chinnery, Patrick F., Surani, M. Azim
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459712/
https://ncbi.nlm.nih.gov/pubmed/26046444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.053
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