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A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development
Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for development. We show that the transcriptional program of hPGCs is distinct from that in mice, with co-expression of somatic specifiers and naive pluripotency genes TFCP2L1 and KLF4. This unique gene regulatory network,...
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| Vydáno v: | Cell |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cell Press
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4459712/ https://ncbi.nlm.nih.gov/pubmed/26046444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.053 |
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