A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for development. We show that the transcriptional program of hPGCs is distinct from that in mice, with co-expression of somatic specifiers and naive pluripotency genes TFCP2L1 and KLF4. This unique gene regulatory network,...

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Published in:Cell
Main Authors: Tang, Walfred W.C., Dietmann, Sabine, Irie, Naoko, Leitch, Harry G., Floros, Vasileios I., Bradshaw, Charles R., Hackett, Jamie A., Chinnery, Patrick F., Surani, M. Azim
Format: Artigo
Language:Inglês
Published: Cell Press 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459712/
https://ncbi.nlm.nih.gov/pubmed/26046444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.053
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