Sequential enhancer state remodelling defines human germline competence and specification

Germline-soma segregation is a fundamental event during mammalian embryonic development. Here, we establish the epigenetic principles of human primordial germ cell (hPGC) development using in vivo hPGCs and stem cell models recapitulating gastrulation. We show that morphogen-induced remodelling of m...

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Detaylı Bibliyografya
Yayımlandı:Nat Cell Biol
Asıl Yazarlar: Tang, Walfred W.C., Castillo-Venzor, Aracely, Gruhn, Wolfram H., Kobayashi, Toshihiro, Penfold, Christopher A., Morgan, Michael D., Sun, Dawei, Irie, Naoko, Azim Surani, M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2022
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612729/
https://ncbi.nlm.nih.gov/pubmed/35411086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-022-00878-z
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