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Sequential enhancer state remodelling defines human germline competence and specification
Germline-soma segregation is a fundamental event during mammalian embryonic development. Here, we establish the epigenetic principles of human primordial germ cell (hPGC) development using in vivo hPGCs and stem cell models recapitulating gastrulation. We show that morphogen-induced remodelling of m...
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| Publicado no: | Nat Cell Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2022
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7612729/ https://ncbi.nlm.nih.gov/pubmed/35411086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-022-00878-z |
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