Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K+ channel

BACKGROUND AND PURPOSE: We aimed to characterize the pharmacology and electrophysiology of N-[3-(1H-benzimidazol-2-yl)-4-chloro-phenyl]pyridine-3-carboxamide (AZSMO-23), an activator of the human ether-a-go-go-related gene (hERG)-encoded K(+) channel (K(v)11.1). EXPERIMENTAL APPROACH: Automated elec...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Mannikko, R, Bridgland-Taylor, M H, Pye, H, Swallow, S, Abi-Gerges, N, Morton, M J, Pollard, C E
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459027/
https://ncbi.nlm.nih.gov/pubmed/25684549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13115
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