Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG-encoded potassium channel

BACKGROUND AND PURPOSE: Potencies of compounds blocking K(V)11.1 [human ether-ago-go-related gene (hERG)] are commonly assessed using cell lines expressing the Caucasian wild-type (WT) variant. Here we tested whether such potencies would be different for hERG single nucleotide polymorphisms (SNPs)....

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Bibliographic Details
Main Authors: Männikkö, R, Overend, G, Perrey, C, Gavaghan, CL, Valentin, J-P, Morten, J, Armstrong, M, Pollard, CE
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2010
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Themed Section
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823356/
https://ncbi.nlm.nih.gov/pubmed/19673885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00334.x
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