hERG subunit composition determines differential drug sensitivity

BACKGROUND AND PURPOSE: The majority of human ether-a-go-go-related gene (hERG) screens aiming to minimize the risk of drug-induced long QT syndrome have been conducted using heterologous systems expressing the hERG 1a subunit, although both hERG 1a and 1b subunits contribute to the K(+) channels pr...

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Main Authors: Abi-Gerges, N, Holkham, H, Jones, EMC, Pollard, CE, Valentin, J-P, Robertson, GA
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2011
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188906/
https://ncbi.nlm.nih.gov/pubmed/21449979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01378.x
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