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Increased 14-3-3 phosphorylation observed in Parkinson’s disease reduces neuroprotective potential of 14-3-3 proteins

14-3-3 proteins are key regulators of cell survival. We have previously demonstrated that 14-3-3 levels are decreased in an alpha-synuclein (αsyn) mouse model of Parkinson’s disease (PD), and that overexpression of certain 14-3-3 isoforms is protective in several PD models. Here we examine whether c...

詳細記述

保存先:
書誌詳細
出版年:Neurobiol Dis
主要な著者: Slone, Sunny Rae, Lavalley, Nicholas, McFerrin, Michael, Wang, Bing, Yacoubian, Talene Alene
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458424/
https://ncbi.nlm.nih.gov/pubmed/25862939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.032
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