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Increased 14-3-3 phosphorylation observed in Parkinson’s disease reduces neuroprotective potential of 14-3-3 proteins
14-3-3 proteins are key regulators of cell survival. We have previously demonstrated that 14-3-3 levels are decreased in an alpha-synuclein (αsyn) mouse model of Parkinson’s disease (PD), and that overexpression of certain 14-3-3 isoforms is protective in several PD models. Here we examine whether c...
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| Udgivet i: | Neurobiol Dis |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4458424/ https://ncbi.nlm.nih.gov/pubmed/25862939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.032 |
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