Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease

14-3-3 proteins are important negative regulators of cell death pathways. Recent studies have revealed alterations in 14-3-3s in Parkinson's disease (PD) and the ability of 14-3-3s to interact with α-synuclein (α-syn), a protein central to PD pathophysiology. In a transgenic α-syn mouse model,...

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Autori principali: Yacoubian, T A, Slone, S R, Harrington, A J, Hamamichi, S, Schieltz, J M, Caldwell, K A, Caldwell, G A, Standaert, D G
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998343/
https://ncbi.nlm.nih.gov/pubmed/21152247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2009.4
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