Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis elegans and Mammalian Models of Parkinson's Disease

Disruption of the lysosomal system has emerged as a key cellular pathway in the neurotoxicity of α-synuclein (α-syn) and the progression of Parkinson's disease (PD). A large-scale RNA interference (RNAi) screen using Caenorhabditis elegans identified VPS-41, a multidomain protein involved in ly...

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Vydáno v:J Neurosci
Hlavní autoři: Harrington, Adam J., Yacoubian, Talene A., Slone, Sunny R., Caldwell, Kim A., Caldwell, Guy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621695/
https://ncbi.nlm.nih.gov/pubmed/22323726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2606-11.2012
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