ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

Allele-specific distinctions in the human apolipoprotein E (APOE) locus represent the best-characterized genetic predictor of Alzheimer's disease (AD) risk. Expression of isoform APOEε2 is associated with reduced risk, while APOEε3 is neutral and APOEε4 carriers exhibit increased susceptibility...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Dis Model Mech
Main Authors: Griffin, Edward F., Scopel, Samuel E., Stephen, Cayman A., Holzhauer, Adam C., Vaji, Madeline A., Tuckey, Ryan A., Berkowitz, Laura A., Caldwell, Kim A., Caldwell, Guy A.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398492/
https://ncbi.nlm.nih.gov/pubmed/30683808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.037218
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