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14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson's disease

14-3-3s are a highly conserved protein family that plays important roles in cell survival and interact with several proteins implicated in Parkinson's disease (PD). Disruption of 14-3-3 expression and function has been implicated in the pathogenesis of PD. We have previously shown that increasi...

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Detalhes bibliográficos
Publicado no:Neuroscience
Main Authors: Ding, Huiping, Underwood, Rachel, Lavalley, Nicholas, Yacoubian, Talene A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594956/
https://ncbi.nlm.nih.gov/pubmed/26314634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2015.08.042
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