The R280H X-Ray Cross-Complementing 1 Germline Variant Induces Genomic Instability and Cellular Transformation

X-ray Repair Cross Complementing protein 1 (XRCC1) plays an important role in base excision DNA repair (BER) as a scaffolding protein for BER enzymes. BER is one of the basic DNA repair pathways repairing greater than 20,000 endogenous lesions per cell per day. Proper functioning of XRCC1, one of th...

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Vydáno v:DNA Repair (Amst)
Hlavní autoři: Sizova, Daria V., Keh, Agnes, Taylor, Ben F., Sweasy, Joann B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458331/
https://ncbi.nlm.nih.gov/pubmed/26011397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2015.05.005
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