Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions

Most cases of congenital obstructive nephropathy are the result of ureteropelvic junction obstructions, and despite their high prevalence, we have a poor understanding of their etiology and scarcity of genetic models. The eight-protein exocyst complex regulates polarized exocytosis of intracellular...

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Publicat a:PLoS One
Autors principals: Fogelgren, Ben, Polgar, Noemi, Lui, Vanessa H., Lee, Amanda J., Tamashiro, Kadee-Kalia A., Napoli, Josephine Andrea, Walton, Chad B., Zuo, Xiaofeng, Lipschutz, Joshua H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457632/
https://ncbi.nlm.nih.gov/pubmed/26046524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129346
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