Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions

Most cases of congenital obstructive nephropathy are the result of ureteropelvic junction obstructions, and despite their high prevalence, we have a poor understanding of their etiology and scarcity of genetic models. The eight-protein exocyst complex regulates polarized exocytosis of intracellular...

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Udgivet i:PLoS One
Main Authors: Fogelgren, Ben, Polgar, Noemi, Lui, Vanessa H., Lee, Amanda J., Tamashiro, Kadee-Kalia A., Napoli, Josephine Andrea, Walton, Chad B., Zuo, Xiaofeng, Lipschutz, Joshua H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457632/
https://ncbi.nlm.nih.gov/pubmed/26046524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129346
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